Sunday, February 27, 2022
Machine learning antibiotic prescriptions can help minimize resistance spread
Researchers find personalized antibiotic prescriptions can reduce the emergence of antibiotic resistance.
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Machine learning antibiotic prescriptions can help minimize resistance spread
Researchers find personalized antibiotic prescriptions can reduce the emergence of antibiotic resistance.
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Saturday, February 26, 2022
New state-of-the-art technology collects a unique time series from methane seeps in the Arctic
The K-Lander observatory -- where state-of-the-art technology meets science. A new study presents a unique time series collected by the K-Lander from two distinct methane seepage sites offshore western Svalbard, in the Arctic. This publication links cutting-edge technology with developments in our understanding of the environment and climate, highlighting and constraining uncertainties in current methane estimates from the seepage of methane from the seafloor.
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Researcher urges caution on AI in mammography
Analyzing breast-cancer tumors with artificial intelligence has the potential to improve healthcare efficiency and outcomes, but doctors should proceed cautiously, according to a new editorial.
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Study questions the role of vitamin D2 in human health but its sibling, vitamin D3, could be important for fighting infections
New research has found significant differences between the two types of vitamin D, with vitamin D2 having a questionable impact on human health. However, the study found that vitamin D3 could balance people's immune systems and help strengthen defences against viral infections such as Covid-19.
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Friday, February 25, 2022
How much energy does a dolphin use to swim?
From foraging for prey to evading predators and ship strikes, a dolphin's survival depends on speedy swimming, but burning all that energy can delete the metabolic reserves vital for growth, health and reproduction. A new study provides scientists with a new metric for estimating how much energy wild dolphins expend on swimming -- information that is essential for answering fundamental questions about their physiology and ecology, and for understanding the impacts of human disturbances on them.
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A potential antiviral for SARS and SARS-like coronaviruses
In a new paper, researchers lay out the similarities in biochemical function among PLpros (papain-like proteases) from SARS-CoV-2, SARS-CoV-1, and those of other SARS-like viruses already circulating among bats and other species.
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Immune cells forget (cell) culture shock
A recent study shows that certain immune cells can restore their normal functions when introduced back into the body, even after being multiplied in the laboratory to large numbers -- the results pave the way to new cell therapies.
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Newly diagnosed diabetes in patients with COVID-19 may simply be a transitory form of the blood sugar disorder
A new study shows that blood sugar levels of COVID-19 patients newly diagnosed with diabetes during hospital admission often returned to normal following discharge, and that only eight percent used insulin after one year.
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Thursday, February 24, 2022
How the immune system responds to tissue damage can aid cancer spread
Researchers have uncovered how a process involved in the regeneration of tissue damaged by radiation can aid the spread of cancer.
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Developments in lignin degradation: New microorganisms and enzymes at play
Lignin, a chief component of cell walls in plants, is naturally degraded in the soil. Identifying new microorganisms involved in this degradation can help develop novel lignin breakdown processes in industrial settings. Now, researchers have isolated 8 microorganisms that degrade the lignin model compound 2-phenoxyacetophenone (2-PAP). They found that one of these microbes uses a new, unidentified enzyme to cleave the ether-bonds in 2-PAP, resulting in the formation of phenol and benzoate.
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How a single nerve cell can multiply
Neurons are constantly performing complex calculations to process sensory information and infer the state of the environment. For example, to localize a sound or to recognize the direction of visual motion, individual neurons are thought to multiply two signals. However, how such a computation is carried out has been a mystery for decades. Researchers have now discovered in fruit flies the biophysical basis that enables a specific type of neuron to multiply two incoming signals. This provides fundamental insights into the algebra of neurons -- the computations that may underlie countless processes in the brain.
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'Workhorse' of photovoltaics in tandem with perovskite
So-called PERC cells are used in mass production of silicon solar cells, they are considered the workhorses of photovoltaics, dominating the market. Now two teams have shown that such standard silicon cells are also suitable as a basis for tandem cells with perovskite top cells. Currently, the efficiency of the tandem cell is still below that of optimised PERC cells alone, but could be increased to up to 29.5% through targeted optimization. The research was funded by the German Federal Ministry of Economics as part of a joint project.
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Unravelling the mysteries around type-2 diabetes
For more than 30 years, scientists have been trying to unravel the mystery of how a key biological molecule self assembles into a rogue protein-like substance known as amyloid, which is thought to play a role in the development of type-2 diabetes - a disease that affects 300 million people worldwide. A team of scientists at the University of Leeds has, for the first time, been able to identify the step-by-step changes that take place in the molecule known as human islet amyloid polypeptide, or hIAPP, as it changes into amyloid.
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Wednesday, February 23, 2022
Risks of using AI to grow our food are substantial and must not be ignored, warn researchers
Artificial intelligence (AI) is on the cusp of driving an agricultural revolution, and helping confront the challenge of feeding our growing global population in a sustainable way. But researchers warn that using new AI technologies at scale holds huge risks that are not being considered.
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Mouse study may help doctors choose treatments for leukemia patients
Some genetic mutations linked to leukemia are less than useful guides to making treatment decisions for patients. A new study suggests a group of clinical signs that can be paired with genetic testing to better inform the timing of more aggressive treatment.
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Being near pollinator habitat linked to larger soybean size
Researchers have found that soybean crops planted near pollinator habitat produce larger soybeans than soybean crops that are not planted near pollinator habitat.
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‘Super pest’ Colorado potato beetle has the genetic resources to sidestep our attacks
The Colorado potato beetle has evolved resistance to more than 50 different kinds of insecticides, making the insect a 'super pest' that wreaks havoc on potatoes around the world. New research finds that the beetle achieved this feat largely by turning to a deep pool of diversity within its genome, which allowed different populations across the U.S. to quickly evolve resistance to nearly anything humans have thrown at it.
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Diet, malaria and substance use linked to Pacific preterm births
A new study has found diet, malaria, substance use and a lack of antenatal care services are linked to one in 10 babies in the Pacific Island region being born preterm and of low birth weight.
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Bringing out the best in wild birds on farms
After an E.coli outbreak in 2006 devastated the spinach industry, farmers were pressured to remove natural habitat to keep wildlife -- and the foodborne pathogens they can sometimes carry -- from visiting crops. A study of California strawberry farms found that birds were actually more likely to carry pathogens and eat berries when farms did not have surrounding natural habitat.
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Basis for next-gen bioprocesses
Succinic acid is an important precursor for pharmaceutical and cosmetic products and also serves as a component in biodegradable plastics. It is currently derived mainly from petroleum-based processes. Researchers are using the marine bacterium Vibrio natriegens as a biocatalyst. This could permit the production of succinic acid in sustainable processes using renewable raw materials.
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Agriculture: Global cropland could be almost halved
In the context of trade-offs between land use and biodiversity, geographers have simulated land saving potentials for agriculture.
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How some gut microbes awaken 'zombie' viruses in their neighbors
Gut bacteria brew all sorts of chemicals, but we don't know what most of them do. A new study suggests that one such compound, previously linked to cancer, may serve as a bizarre weapon in microbial skirmishes.
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Tuesday, February 22, 2022
Singing in the brain
For the first time, neuroscientists have identified a population of neurons in the human brain that light up when we hear singing, but not other types of music.
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Monday, February 21, 2022
Seeing 'green' can ease confusion, anger in navigating hospitals
Research has shown that introducing nature into large hospitals can humanize the institutional environment and reduce the stress of patients, visitors and healthcare providers.
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Seeing 'green' can ease confusion, anger in navigating hospitals
Research has shown that introducing nature into large hospitals can humanize the institutional environment and reduce the stress of patients, visitors and healthcare providers.
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Bacteria upcycle carbon waste into valuable chemicals
Researchers engineered a strain of bacteria to break down carbon dioxide (CO2), converting it into commonly used, expensive industrial chemicals. The carbon-negative approach removes CO2 from the atmosphere and bypasses using fossil fuels to generate these chemicals.
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Sunday, February 20, 2022
Hepatitis C patients cured with antiviral medicines are less likely to be hospitalized, need ER care for liver, other health-related issues
Researchers report that patients with chronic hepatitis C who are treated with direct-acting antiviral medicines are less likely to be hospitalized or seek emergency care for liver and non-liver related health issues. The study underscores the extraordinary effect of these newer antivirals, which have been shown to cure hepatitis C in 98 percent of patients who take them.
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Steroid treatments for Duchenne muscular dystrophy may depend on the clock
Latest advance in chronopharmacology, based on mouse models, suggests that time-of-day matters when using steroids to treat muscle diseases.
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Saturday, February 19, 2022
Predicting and preparing for the impact of approaching storms
Climate experts and engineers have created a new model to predict the damage caused by adverse weather. This new framework for 'consequence forecasting' enables first responders to effectively target resources prior to an extreme weather event, such as Storm Eunice.
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A possible paradigm shift within piezoelectricity
Researchers have found a new method to induce the piezoelectric effect in materials that are otherwise not piezoelectric. It can pave the way for new uses and more environmentally friendly materials.
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Scientists characterize the imbalanced gut bacteria of patients with myocardial infarction, angina and heart failure
Researchers show how major disturbances occur in the gut microbiome of patients suffering from heart disease. Given this latest evidence from microbiome research, researchers now call for stronger and more focused public health initiatives to prevent or delay these common diseases that are a leading cause of premature death worldwide through encouraging a plant-based and energy-controlled diet, avoidance of smoking and compliance with daily exercise.
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Scientists characterize the imbalanced gut bacteria of patients with myocardial infarction, angina and heart failure
Researchers show how major disturbances occur in the gut microbiome of patients suffering from heart disease. Given this latest evidence from microbiome research, researchers now call for stronger and more focused public health initiatives to prevent or delay these common diseases that are a leading cause of premature death worldwide through encouraging a plant-based and energy-controlled diet, avoidance of smoking and compliance with daily exercise.
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Friday, February 18, 2022
Gut health compromised in severe COVID-19
New research of samples of intestine from people who have died of COVID-19 has shown the impact of the virus on the gut immune system.
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Review of technologies that repurpose carbon finds most aren’t Paris Agreement compatible
As the climate crisis becomes more immediate, carbon capture and utilization (CCU) technology has been touted as part of the solution. The process involves harnessing carbon dioxide from emissions or the atmosphere and repurposing them. However, a recent review calls into question the viability of many of these methods to meet both the long-term and short-term emissions goals that follow from the Paris Agreement, and suggests focusing on technologies that use non-fossil carbon dioxide and store carbon permanently.
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Treatment for Parkinson’s could now get even better
Specialized groups of neurons within the brainstem control movement. Now researchers have found that activation of such neurons is sufficient to restore full movement function in mice with symptoms of Parkinson's Disease. The study helps clinicians to focus Deep Brain Stimulation to the right therapeutic spot and hopefully could improve treatment of motor symptoms in Parkinson's Disease.
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Researchers identify protein complex critical in helping control cell death
A pathway critical for regulating a form of cell death known as necroptosis has been identified. The team's preclinical findings suggest that an inhibitor targeting this PPP13RG protein complex can help prevent or reduce deaths and severe tissue damage from heart attacks and other inflammation-associated diseases.
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Researchers identify protein complex critical in helping control cell death
A pathway critical for regulating a form of cell death known as necroptosis has been identified. The team's preclinical findings suggest that an inhibitor targeting this PPP13RG protein complex can help prevent or reduce deaths and severe tissue damage from heart attacks and other inflammation-associated diseases.
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Thursday, February 17, 2022
Size matters in particle treatments of traumatic injuries
Chemical engineers tested how different-sized polymer nanoparticles circulate in the body and interact with platelets, the cells that promote blood clotting. Such particles could be used to help stop internal bleeding after traumatic injuries.
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New DNA computer assesses water quality
Synthetic biologists have developed a low-cost, easy-to-use, hand-held device that can let users know -- within mere minutes -- if their water is safe to drink. The new device works by using powerful and programmable genetic networks, which mimic electronic circuits, to perform a range of logic functions.
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Depression and Alzheimer’s disease share genetic roots
Epidemiological data have long linked depression with Alzheimer’s disease (AD), a neurodegenerative disease characterized by progressive dementia that affects nearly 6 million Americans. Now, a new study identifies common genetic factors in both depression and AD. Importantly, the researchers found that depression played a causal role in AD development, and those with worse depression experienced a faster decline in memory.
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Elephant sharks offer a novel perspective on how humans evolved
Researchers have used an ancient fish to reel in new insights about human biology and, in particular, how and why a widely used medication works to abort pregnancies (in people, not fish).
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MRI may lower breast cancer deaths from variants in 3 genes
Annual MRI screenings starting at ages 30 to 35 may reduce breast-cancer mortality by more than 50% among women who carry certain genetic changes in three genes, according to a comparative modeling analysis. The predictions involve pathogenic variants in ATM, CHEK2 and PALB2 genes -- which collectively are as prevalent as the much-reported BRCA1/2 gene mutations.
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Wednesday, February 16, 2022
Heart attack survivors may be less likely to develop Parkinson’s disease
People who have had a heart attack are at increased risk of stroke and vascular dementia; however, a new study found they may be less likely to develop Parkinson's disease. A large, nationwide study in Denmark found that the risk of Parkinson's disease was moderately lower among people who have had a heart attack than among the general population.
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Stem cell infusion boosts sepsis survival in mice
A one-time infusion of stem cells from bone marrow improves the survival of mice with sepsis.
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Where children live linked to delayed access to surgical care
A new study found that children from less resourced neighborhoods were at increased odds of presenting with complicated appendicitis, an indicator of delayed access to surgical care. This is the first pediatric study to link many neighborhood-level factors that influence health -- such as quality of schools, housing, safety, and economic opportunity -- to timely surgical care access.
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SARS-CoV-2 protein targeted by immune cells also triggers response in bat coronaviruses, study shows
A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans -- including SARS-CoV-2, the cause of COVID-19 -- may be possible, say researchers.
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Sudden evolutionary change
Researchers have identified a case of a sudden evolutionary change. In a new study, the scientists describe a population of columbines that have lost their petals, including the characteristic nectar spurs. The finding adds weight to the idea that adaptation can occur in large jumps, rather than merely plodding along over extended timespans.
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SARS-CoV-2 protein targeted by immune cells also triggers response in bat coronaviruses, study shows
A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans -- including SARS-CoV-2, the cause of COVID-19 -- may be possible, say researchers.
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Tuesday, February 15, 2022
'Blue Blob' near Iceland could slow glacial melting
A region of cooling water in the North Atlantic Ocean near Iceland, nicknamed the 'Blue Blob,' has likely slowed the melting of the island's glaciers since 2011 and may continue to stymie ice loss until about 2050, according to new research.
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COVID-19 vaccination boosts mental health along with immunity, study finds
Receiving at least one vaccine dose was associated with statistically significant declines in multiple psychological distress factors, researchers report in a new study.
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Beset in mucus, coronavirus particles likely travel farther than once thought, study finds
A modeling study raises questions about how far droplets, like those that carry the virus that causes COVID-19, can travel before becoming harmless.
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How a protein controls the production of nerve cells in the brain
Researchers have discovered that the protein YME1L regulates the production of new nerve cells and the maintenance of neural stem cells in the adult brain. This holds great potential for regenerative treatments after brain injuries and other diseases.
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Computer models show how crop production increases soil nitrous oxide emissions
A computer modeling study shows how the emissions of the greenhouse gas nitrous oxide have increased from soils over the last century. The newly published research found the expansion of land devoted to agriculture since 1900 and intensive fertilizer inputs have predominantly driven an overall increase in nitrous oxide emissions from U.S. soils.
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Discovery of ancient plant fossils in Washington points to paleobotanic mystery
A new description of two well-preserved ancient fossil plant specimens in Washington state is prompting paleobotanists to rethink how plants might have been dispersed during the Late Cretaceous, between 66 and 100 million years ago.
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Sunday, February 13, 2022
Saturday, February 12, 2022
Friday, February 11, 2022
Exploring the signals that underlie learning
When you start learning how to do something new, like playing a musical instrument, the simplest tasks can feel difficult. But as you gain experience, you play with ease and without conscious thought. Researchers are mapping the signals that correlate with adaptive behavior and learning.
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Black Death mortality not as widespread as long thought
A new study used pollen data to evaluate the second plague pandemic's mortality at a regional scale across Europe. Results showed that the impacts of the Black Death varied substantially from region to region and demonstrated the importance of cross-disciplinary approaches for understanding past -- and present -- pandemics.
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Black Death mortality not as widespread as long thought
A new study used pollen data to evaluate the second plague pandemic's mortality at a regional scale across Europe. Results showed that the impacts of the Black Death varied substantially from region to region and demonstrated the importance of cross-disciplinary approaches for understanding past -- and present -- pandemics.
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Researchers make non-alcoholic beer taste like regular beer
Finally, researchers have found a way to brew non-alcoholic beer that tastes just like regular beer. Even more, the method is far more sustainable than the existing brewing techniques.
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Lifetime of knowledge can clutter memories of older adults
When a person tries to access a memory, their brain quickly sifts through everything stored in it to find the relevant information. But as we age, many of us have difficulty retrieving memories. Researchers propose an explanation for why this might be happening: the brains of older adults allocate more space to accumulated knowledge and have more material to navigate when attempting to access memories. While this wealth of prior knowledge can make memory retrieval challenging, the researchers say it has its upsides -- this life experience can aid with creativity and decision-making.
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This bizarre looking helmet can create better brain scans
Researchers have developed a dome-shaped device, which fits over a person's head and can be worn during a brain scan, that boosts MRI performance, creating crisper images that can be captured at twice the normal speed. Eventually, the magnetic metamaterial has the potential to be used in conjunction with cheaper low-field MRI machines to make the technology more widely available, particularly in the developing world.
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Thursday, February 10, 2022
Brainy birds may fare better under climate change
Many North American migratory birds are shrinking in size as temperatures have warmed over the past 40 years. But those with very big brains, relative to their body size, did not shrink as much as smaller-brained birds, according to new research. The study is the first to identify a direct link between cognition and animal response to human-made climate change.
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Your microbiome shapes your life. But where did it come from?
The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they get there in the first place? New research reveals crucial details about how the bacterial communities that comprise each of our individual gut microbiomes are acquired. These findings have major implications for treatments such as fecal transplants and probiotic administration.
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Your microbiome shapes your life. But where did it come from?
The gut microbiome is an ecosystem of hundreds to thousands of microbial species living within the human body. These populations affect our health, fertility, and even our longevity. But how do they get there in the first place? New research reveals crucial details about how the bacterial communities that comprise each of our individual gut microbiomes are acquired. These findings have major implications for treatments such as fecal transplants and probiotic administration.
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Musical preferences unite personalities worldwide, new study finds
Research involving more than 350,000 participants from over 50 countries and 6 continents has found that links between musical preferences and personality are universal. The findings suggest that music could play a greater role in overcoming social division, as well as offering currently untapped therapeutic benefits.
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In animal battles, cheaters can win
Animal weapons can be a lot like plastic swords: impressive, but ultimately cheap. Some animals pretend to be bigger than they are by building weapons out of metabolically cheap inert materials, such as chitin and keratin. The prop weapons are also cheaper to maintain.
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Delta vs. Kappa: Study examines molecular factors that fuel COVID-19 variants
Researchers are shedding new light on the molecular factors that give COVID-19 variants a competitive edge -- essential knowledge that could improve disease management as new variants continue to emerge. The findings explain how the Delta variant may have been able to beat out the Kappa variant and become dominant across the globe.
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Wednesday, February 9, 2022
Agricultural fungicides may be driving antimicrobial resistance
New research has shown that compounds used to fight fungal diseases in plants are likely causing resistance to antifungal medications used to treat people.
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Immune cells leave fingerprints on tumors metastasized to the brain offering clues to future therapies
Using data from over 100,000 malignant and non-malignant cells from 15 human brain metastases, researchers have revealed two functional archetypes of metastatic cells across 7 different types of brain tumors, each containing both immune and non-immune cell types. Their findings provide a potential roadmap for metastatic tumor formation that could be used to design therapies to improve the treatment of metastasized patients.
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Identification of a unique 'switch' for blood vessel generation
Researchers discover a 'switch' specific to transcription factors that induce the genes essential for blood vessel development in postnatal periods. Mouse models further showed that the modifiers responsible for the switch are critical for postnatal angiogenesis.
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Potential target for treating osteoporosis
Channels on the surface of bone cells called osteocytes help build stronger bones in response to mechanical stress, shows a new study.
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Tuesday, February 8, 2022
Genome of Steller’s sea cow decoded
During the Ice Age, giant mammals such as mammoths, sabre-toothed cats and woolly rhinoceroses once roamed Northern Europe and America. The cold oceans of the northern hemisphere were also home to giants like Steller's sea cow, which grew up to eight meters long and weighed up to ten tons, and has been extinct for around 250 years. Now an international research team has succeeded in deciphering the genome of this ice-age species from fossil bones. They also found an answer to the question of what the genome of this extinct species of sea cow reveals about present-day skin diseases.
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Important step towards fasting-based therapies
Voluntary fasting, for example interval fasting, is beneficial to health for many people, depending on their individual condition. For example, controlled periods of starvation can prevent and improve diseases such as diabetes and obesity. Researchers have now found that the immune system plays an important role in ensuring the positive effects of fasting on our bodies. The new findings will help develop more effective therapies based on fasting.
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A new multipurpose on-off switch for inhibiting bacterial growth
Researchers have discovered an antitoxin mechanism that seems to be able to neutralize hundreds of different toxins and may protect bacteria against virus attacks. The mechanism has been named Panacea, after the Greek goddess of medicine whose name has become synonymous with universal cure. The understanding of bacterial toxin and antitoxin mechanisms will be crucial for the future success of so-called phage therapy for the treatment of antibiotic resistance infections, the researchers say.
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Important step towards fasting-based therapies
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Unique seagrass nursery aims to help Florida's starving manatees
More than 1,000 manatees died in 2021, due mostly to starvation. They consume about 100 pounds of seagrass a day, and this staple food is now scarce in Florida's Indian River Lagoon (IRL). A new study shows that about 7,400 acres of seagrasses were lost in the IRL between 1943 and 1994. Between 2011 and 2019, about 58 percent of seagrasses were lost. To help with recovery efforts, researchers are experimenting with growing seagrass in large tanks and then transplanting it into the IRL to try to restore some of the lost seagrass beds.
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Monkeys, like people, can 'choke under pressure'
Being stressed about doing well on a test might not be limited to humans, according to a new study.
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Giant sponge gardens discovered on seamounts in the Arctic deep sea
Massive sponge gardens thrive on top of seamounts in the Central Arctic Ocean, one of the most oligotrophic seas on Earth. They appear to feed on the remnants of an extinct fauna. Microorganisms support the sponges in exploiting this fluffy material as a source of food and energy.
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Monday, February 7, 2022
Genetic remodeling in tumor formation
A new study demonstrates the ability of the mutant Kras oncogene to use genetic reprogramming to make cells more stem-like and plastic; it resolves the long-standing debate over why Kras is so special in tumor formation. They were also able to identify an effector complex that can be targeted for therapeutic treatment against mutant Kras.
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Sunday, February 6, 2022
Venomous Australian sea anemone may lead to life-saving drugs
An entirely new toxic compound found in an Australian tropical sea anemone is being analysed as a potential new drug therapy, after it was discovered by biomolecular scientists during investigation of the species' multiple venoms.
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Underwater 'breathing' plants could be key to stress-resistant crops
Wetland plants have a high tolerance against flooding due to the formation of 'lysigenous aerenchyma,' air channels that help transfer gases to the submerged roots. These channels also help the plant withstand drought and nutrient deficiency. Now, scientists investigate the underlying mechanism of aerenchyma formation to understand the phenomenon better, opening doors to the development of crops that are resilient against extreme weather changes.
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One in four Australian workers suffer ‘ringing ears’, survey shows
As many as half a million Australians are suffering from constant tinnitus, with farmers, automotive workers, transport drivers, construction workers and other trades people at the greatest risk, a national survey has found.
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Pre-infection deficiency of vitamin D is associated with increased disease severity and mortality among hospitalized COVID-19 patients
In a new study, researchers show a correlation between vitamin D deficiency and COVID-19 severity and mortality. The study is among the first to analyze vitamin D levels prior to infection, which facilitates a more accurate assessment than during hospitalization, when levels may be lower secondary to the viral illness.
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Saturday, February 5, 2022
Preventing pandemics costs far less than controlling them
An analysis by epidemiologists, economists, ecologists and biologists at 21 institutions finds we could reduce the risks of future pandemics by investing as little as 1/20th of the losses incurred so far from COVID into conservation measures designed to stem the spread of zoonotic viruses from wildlife to humans in the first place. This includes funding programs to train more veterinarians, create a global database of virus genomics, and end tropical deforestation and wildlife trafficking.
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Preventing pandemics costs far less than controlling them
An analysis by epidemiologists, economists, ecologists and biologists at 21 institutions finds we could reduce the risks of future pandemics by investing as little as 1/20th of the losses incurred so far from COVID into conservation measures designed to stem the spread of zoonotic viruses from wildlife to humans in the first place. This includes funding programs to train more veterinarians, create a global database of virus genomics, and end tropical deforestation and wildlife trafficking.
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Friday, February 4, 2022
The abyssal world: Last terra incognita of the Earth surface
The first unified vision of the world ocean biodiversity, based on analysis of DNA sequences from the surface to deep-ocean sediments, unveils the rich and unknown life in the abyssal realm, the last terra incognita of the Earth surface. This collective effort was made possible by 15 international deep-sea expeditions.
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Widely-used hormone drug associated with increased risk of benign brain tumor at high doses
High doses of a widely-used drug used in the hormonal treatment of conditions such as excessive hair growth, early puberty, prostate cancer, are linked to an increased risk of meningioma -- the most common type of benign brain tumor, finds a new study of over 8-million patients.
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How our body controls inflammation during clean-up mechanisms of damaged cells
A research team has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body. Using high-resolution microscopy methods, the researchers were able to show that two proteins interact dynamically with each other and thus determine whether a dying cell triggers an inflammatory reaction in the body.
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Those at highest risk for severe COVID-19 often least likely to get monoclonal antibodies, study finds
People over age 65 at the highest risk for severe COVID-19 have often been the least likely to receive monoclonal antibodies (mAbs) -- a highly effective treatment for the disease -- both across and within U.S. states, according to new research.
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How our body controls inflammation during clean-up mechanisms of damaged cells
A research team has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body. Using high-resolution microscopy methods, the researchers were able to show that two proteins interact dynamically with each other and thus determine whether a dying cell triggers an inflammatory reaction in the body.
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How long-term cannabis use can damage lungs
Smoking cannabis leads to lung damage, but in a different way to tobacco, new research has found. The findings come from the long-running Dunedin Multidisciplinary Health and Development Study, which has documented cannabis use and measured lung function throughout adult life up to age 45 in more than 1,000 individuals born in Dunedin, New Zealand in 1972/73.
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Thursday, February 3, 2022
Exploring the strategies of categorization
Our mental ability to divide the complex world into categories makes our daily life much easier. But how do we categorize? What kind of stimulus properties do we assess? Researchers have come a step closer to answering these questions with the help of pigeons. They discovered that birds use different strategies to successfully learn categories. To gather data, the researchers used a novel research method. To this end, they combined so-called virtual phylogenesis, in which artificial stimuli are generated by computers, with a machine learning approach, namely an automated evaluation of the birds' pecking behavior.
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Scientists test promising biosensor aimed for use in brain
Scientists have successfully tested in the lab a tiny biosensor they developed that can detect biomarkers tied to traumatic brain injuries.
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What a salamander virus can tell us about the future of biodiversity amid a changing climate
The 'Ebola virus of the amphibian world' is as unpleasant as it sounds, but a species of salamander that lives in Arizona found a way to live with the endemic disease. As the climate changes, viruses change along with it, and this unpredictable virus could have a more severe effect on different species in the future.
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More spice could help seniors avoid salt
Add a little spicy seasoning to a low sodium meal, and adults over the age of 60 may have a harder time noticing a lack of salt, according to a new study. The study tested saltiness perception in older adults using white sauce formulations with varying amounts of salt and different spices and seasonings added.
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Scientists detect novel SARS-CoV-2 variants in NYC wastewater
Researchers have detected at least four 'cryptic' variants of SARS-CoV-2, the virus that causes COVID-19, in samples of wastewater from New York City's public sewer system.
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Scientists detect novel SARS-CoV-2 variants in NYC wastewater
Researchers have detected at least four 'cryptic' variants of SARS-CoV-2, the virus that causes COVID-19, in samples of wastewater from New York City's public sewer system.
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Wednesday, February 2, 2022
Different autism risk genes, same effects on brain development
Researchers have found that three different autism risk genes actually affect similar aspects of neuron development and the same neuron types, although each gene acted through unique molecular mechanisms. Additionally, a person's specific genomic background fine-tuned the genes' effects. The study was conducted using miniature 3D models, or 'organoids,' of the human cerebral cortex, the part of the brain responsible for cognition, perception, and language. The results advance our understanding of autism spectrum disorder and are a first step toward finding treatments for the condition.
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Untangling a DNA replication mystery may lead to new antimalarial drugs
The function of an enzyme, critical to most forms of life, has been revealed.
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Predicting cell fates: Researchers develop AI solutions for next-gen biomedical research
Data is not only the answer to numerous questions in the business world; the same applies to biomedical research. In order to develop new therapies or prevention strategies for diseases, scientists need more and better data, faster and faster. However, the quality is often very variable and the integration of different data sets often almost impossible.
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Cancer treatment: A berry from Brazil helps out
Castalagin, a polyphenol from the Amazonian fruit camu-camu, increases the efficacy of immunotherapy in mice by modifying their microbiome, researchers find.
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Scientists uncover 'missing' plastics deep in the ocean
A new study unveils the prevalence of plastics in the entire water column of an offshore plastic accumulation zone in the southern Atlantic Ocean and implicates the ocean interior as a crucial pool of 'missing' plastics. Results show that small microplastics are critical, underexplored and integral to the oceanic plastic inventory. In addition, findings show that weak ocean current systems contribute to the formation of small microplastics hotspots at depth, suggesting a higher encounter rate for subsurface particle feeders like zooplankton.
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The last ice age widened the Aare and Gürbe valleys
A team was able to prove that the glaciers of the penultimate ice age ('Riss' glaciation) mainly eroded the bedrock between Thun and Bern, but that during the last glaciation (' Würm'- glaciation) glacial carving resulted in a widening and not in a further deepening of the valleys. The researchers reconstructed the geometry of the bedrock using gravity measurements to reach their conclusions.
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Genome study finds unexpected variation in a fundamental RNA gene
A genome study to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.
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Tuesday, February 1, 2022
Promising results of Phase 1 drug trial for HIV patients
A Phase 1 clinical trial has demonstrated the safety and efficacy of a novel immunotherapy drug in the treatment of HIV.
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Treatment keeps alcoholic monkeys from drinking as much
A hormone produced by the liver called fibroblast growth factor 21 (FGF21) suppresses alcohol consumption in primates, finds a new study. Vervet monkeys with a strong preference for ethanol that were given an FGF21 analogue consumed 50% less alcohol. The study also studied the brain circuits involved in mice and found that the protein, known to also reduce sugar intake, acts on different circuits to reduce alcohol and sugar consumption.
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First records of killer whales hunting largest animals on Earth
In late March 2019, researchers performing annual whale and dolphin research surveys discovered the first ever record of killer whales hunting and killing an adult blue whale. Just two weeks later a blue whale calf was taken by many of the same individuals. Since then, an additional event of another blue whale calf predation was recorded in 2021.
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Promising results of Phase 1 drug trial for HIV patients
A Phase 1 clinical trial has demonstrated the safety and efficacy of a novel immunotherapy drug in the treatment of HIV.
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