Global opioid sales increased by an estimated 4% annually from 2015 to 2019, but massive disparities in access to essential pain relief medications persist between countries, a new study finds.
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Thursday, March 31, 2022
Those who ogle also more likely to have harmful attitudes, study finds
New research examining 'eye gaze behavior' has found that looking at people's bodies, rather than their faces, is linked with harmful attitudes towards sexual assault.
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African network protects key turtle sites
A network of West African Marine Protected Areas (MPAs) covers key sites used by green turtles, new research shows.
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Married mothers who earn more than their husbands take on an even greater share of the housework, research finds
While new mothers frequently take on a greater share of housework than their spouses, this effect is even more pronounced in mothers who earn more than fathers, new research shows.
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Researchers outline bias in epidemic research -- and offer new simulation tool to guide future work
A team of researchers unpacks a series of biases in epidemic research, ranging from clinical trials to data collection, and offers a game-theory approach to address them, in a new analysis. The work sheds new light on the pitfalls associated with technology development and deployment in combating global crises like COVID-19, with a look toward future pandemic scenarios.
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Wednesday, March 30, 2022
Americans love football, but differ on whether kids should play
Football may be America's most popular sport, but the nation is deeply divided about whether youth should play the tackle version of the game.
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Where we grow up influences our sense of direction
New researcher has demonstrated that people's spatial navigation ability is influenced by their geographical origin. Growing up in rural or urban areas, or in cities of varying complexity, influences our sense of direction in adulthood. These results were obtained using data collected from the video game Sea Hero Quest.
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Exercise may reduce depression symptoms, boost effects of therapy
Exercising for half an hour may reduce symptoms of depression for at least 75 minutes post-workout and amplify the benefits of therapy, according to two new studies.
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The Rule of Two helps make spaces sound better
Researchers developed a new acoustic measurement technique in a room with more acoustic combinations than there are ants on Earth.
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Where we grow up influences our sense of direction
New researcher has demonstrated that people's spatial navigation ability is influenced by their geographical origin. Growing up in rural or urban areas, or in cities of varying complexity, influences our sense of direction in adulthood. These results were obtained using data collected from the video game Sea Hero Quest.
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Tuesday, March 29, 2022
Researchers shorten manufacturing time for CAR T cell therapy
A new approach could cut the time it takes to alter patients' immune cells for infusion back into the body to find and attack cancer. The cell manufacturing process for this type of immunotherapy that was pioneered at Penn -- CAR T cell therapy -- typically takes nine to 14 days. In a pre-clinical study, scientists have abbreviated this process and generated functional CAR T cells with enhanced anti-tumor potency in just 24 hours.
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Promising Alzheimer's drug may also improve memory in Down syndrome and normal aging
New research is breaking ground in repurposing an FDA-approved drug as a potential treatment in Down syndrome and normal aging. The results suggest that GM-CSF may improve cognitive function in people with Down syndrome. The drug sargramostim (GM-CSF, which stands for granulocyte-macrophage colony-stimulating factor) is also the first to show memory improvement in Alzheimer's patients in a phase II clinical trial. GM-CSF is a normal human protein that is safe and well-tolerated with over 30 years of FDA-approved use for other disorders.
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Lung damage may persist long after COVID-19 pneumonia
Some people recovering from COVID-19 pneumonia have CT evidence of damage to their lungs that persists a full year after the onset of symptoms, according to a new study.
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AI helps radiologists detect bone fractures
Artificial intelligence (AI) is an effective tool for fracture detection that has potential to aid clinicians in busy emergency departments, according to a new study.
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Distinct classes of fibroblasts in tumors play opposing roles, promoting or restraining pancreatic cancer growth
Researchers discovered that two distinct classes of fibroblast cells accumulate in pancreatic tumors and play opposing roles to promote and restrain pancreatic cancer growth. Appropriately targeting these cells may offer options to improve treatment outcomes.
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Dried avocado meal, a novel fiber source to be added to commercial dog food
Thanks to avocados' rise to superfood stardom, there are now more avocado-derived products in the supply chain than ever. In a unique study, researchers looked at the possibility of using avocado meal -- the ground, dried, and defatted pulp, seed, and skin left over after avocado oil processing -- as a fiber source in dry dog food.
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Good hydration may reduce long-term risks for heart failure
Staying well-hydrated may be associated with a reduced risk for developing heart failure. New findings suggest that consuming sufficient amounts of fluids throughout life not only supports essential body functioning but may also reduce the risk of severe heart problems in the future.
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Osmotic pressure and viscosity: Anticancer drug efficacy and restricting tumors using LDDS
Chemotherapy is known for its painful side-effects. It also has limitations when the cancer has metastasized to the lymph nodes. The lymphatic drug delivery system, where anticancer drugs are injected directly into the sentinel lymph nodes under ultrasound guidance, offers an alternative to conventional chemotherapy. Researchers have now found the optimal osmotic pressure and viscosity ranges, significantly improving the antitumor effect.
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Monday, March 28, 2022
Sunday, March 27, 2022
Saturday, March 26, 2022
COVID-19 mixed with flu increases risk of severe illness and death
Adults in hospital who have COVID-19 and the flu at the same time are at much greater risk of severe disease and death compared with patients who have COVID-19 alone or with other viruses, research shows.
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New study reveals why HIV remains in human tissue even after antiretroviral therapy
Thanks to antiretroviral therapy, HIV infection is no longer the life sentence it once was. But despite the effectiveness of drugs to manage and treat the virus, it can never be fully eliminated from the human body, lingering in some cells deep in different human tissues where it goes unnoticed by the immune system. Now, new research by University of Alberta immunologist Shokrollah Elahi reveals a possible answer to the mystery of why infected people can't get rid of HIV altogether. Elahi and his team found that in HIV patients, killer T cells -- a type of white blood cells responsible for identifying and destroying cells infected with viruses -- have very little to none of a protein called CD73. Because CD73 is responsible for migration and cell movement into the tissue, the lack of the protein compromises the ability of killer T cells to find and eliminate HIV-infected cells, explained Elahi.
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Friday, March 25, 2022
Large study challenges the theory that light alcohol consumption benefits heart health
In an observational analysis of UK Biobank participants, light to moderate drinkers had the lowest heart disease risk, followed by people who abstained from drinking; however, light to moderate drinkers tended to have healthier lifestyles than abstainers, which likely accounted for their better heart health. Genetic evidence in this same population suggested that all levels of alcohol intake are associated with increased cardiovascular risk. Notably, the risk of cardiovascular disease linked to light alcohol consumption was modest but rose exponentially with higher intake, even at intake levels currently endorsed as 'low risk.'
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Study finds neurons that encode the outcomes of actions
A group of neurons in the brain's striatum encodes information about the potential outcomes of different decisions. These cells become particularly active when a behavior leads a different outcome than what was expected, which the researchers believe helps the brain adapt to changing circumstances.
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Breakthrough application of moisture-trapping film to reduce heat stress in personal protective suits
Researchers have developed a novel super-hygroscopic material that enhances sweat evaporation within a personal protective suit, to create a cooling effect for better thermal comfort for users such as healthcare workers and other frontline officers. With this innovation, users will feel 40% cooler and their risk of getting heat stroke is lowered significantly.
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Vagus nerve stimulation lowers costs of care for children with uncontrolled epilepsy
A new study has examined a population of pediatric patients with drug-resistant epilepsy. For these patients, the study found that the patients who received vagus nerve stimulation (VNS), when used with anti-seizure medications (ASM), had lower hospital costs compared to the use of ASM alone. The study found that the patients treated with ASM plus VNS had savings of over $3,000 of epilepsy-related annual costs per year, compared to treatment with ASM only.
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Study shows how bioactive substance inhibits important receptor
The A2A receptor regulates how vigorously the innate immune system attacks diseased cells. Researchers have now been able to show for the first time how an important inhibitor binds to the receptor. In the future, the results will facilitate the targeted search for molecules that give the innate immune system more punch. These could for instance be used in the fight against cancer, but also against brain diseases such as Alzheimer's or Parkinson's disease.
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Win-wins in environmental management hard to find
When a booming marine fishery can increase its shrimp catch while also reducing unintentional bycatch of turtles --t hat's an example of what environmental scientists and managers call a 'win-win.' Models often predict this ideal outcome is achievable, yet stakeholders rarely see it manifest in the real world.
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Innovative AI technology aids personalized care for diabetes patients needing complex drug treatment
Medical researchers have developed and tested an AI method to improve care for patients with type 2 diabetes mellitus who need complex treatment. The new AI method analyzed electronic health record data across Utah and Indiana and learned generalizable treatment patterns of type 2 diabetes patients with similar characteristics. Those patterns can now be used to help determine an optimal drug regimen for a specific patient.
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Thursday, March 24, 2022
Warming oceans are getting louder
Climate change is speeding sound transmission in the oceans and the way it varies over the globe with physical properties of the oceans. Two 'acoustic hotspots' of future sound speed increases are predicted east of Greenland and in the Northwest Atlantic Ocean, East of Newfoundland. In these locations, the average speed of sound is likely to increase by more than 1.5% if 'business-as-usual' high rates of greenhouse gas emissions continue through 2100.
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Novel therapy could help people with asthma, COPD, cystic fibrosis and cancer-related lung disease
Scientists have developed a drug to treat the uncontrolled secretion of mucins in the airways, which causes potentially life-threatening symptoms in millions of Americans with lung diseases.
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Health risk due to micro- and nanoplastics in food
Five grams of plastic particles on average enter the human gastrointestinal tract per person per week. This is roughly equivalent to the weight of a credit card. Whether ingested micro- and nanoplastics pose a health risk is being investigated in numerous studies but is largely unknown to date. A research team has now summarized the current state of scientific knowledge.
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Health risk due to micro- and nanoplastics in food
Five grams of plastic particles on average enter the human gastrointestinal tract per person per week. This is roughly equivalent to the weight of a credit card. Whether ingested micro- and nanoplastics pose a health risk is being investigated in numerous studies but is largely unknown to date. A research team has now summarized the current state of scientific knowledge.
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Male dolphins whistle to maintain key social relationships
Allied male bottlenose dolphins maintain weaker yet vital social relationships with whistle exchanges, researchers have found.
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Revamped design could take powerful biological computers from the test tube to the cell
Researchers may have developed long-lived biological computers that could potentially persist inside cells. Researchers forgo the traditional DNA-based approach, opting instead to use the nucleic acid RNA to build computers. The results demonstrate that the RNA circuits are as dependable and versatile as their DNA-based counterparts. What's more, living cells may be able to create these RNA circuits continuously, something that is not readily possible with DNA circuits.
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Wednesday, March 23, 2022
Humans have given wild animals their diseases nearly 100 times, researchers find
Scientists have found that humans might give viruses back to animals more often than previously understood.
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Chemical found in leafy greens shown to slow growth of COVID-19 and common cold viruses
A study in mice and lab-grown cells finds sulforaphane could help prevent and treat illnesses caused by certain coronaviruses, including COVID-19.
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One in three children with disabilities globally have experienced violence in their lifetimes, study finds
Children and adolescents (aged 0-18 years) with disabilities experience physical, sexual, and emotional violence, and neglect at considerably higher rates than those without disability, despite advances in awareness and policy in recent years. This is according to a systematic review of research involving more than 16 million young people from 25 countries conducted between 1990 and 2020. The study provides the most comprehensive picture of the violence experienced by children with disabilities around the world.
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Humans have given wild animals their diseases nearly 100 times, researchers find
Scientists have found that humans might give viruses back to animals more often than previously understood.
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Atossa – The protein queen commanding cell invasion
Immune cells are our body's police force, but how can they reach the crime scene fast? Researchers have now discovered a new protein that boosts energy production inside immune cells and thus increases their power to invade. Apart from improving immune responses, the results could revolutionize our understanding of energy regulation in cells throughout the human body.
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New method of pancreatic islet cryopreservation marks breakthrough for diabetes cure
Engineering and medical researchers have developed a new process for successfully storing specialized pancreatic islet cells at very low temperatures and rewarming them, enabling the potential for on-demand islet transplantation. The breakthrough discovery in cryopreservation is a major step forward in a cure for diabetes.
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Tuesday, March 22, 2022
Agricultural expansion a major cause to doubling of annual tropical carbon loss over past two decades
Using multiple high-resolution satellite datasets, researchers found that tropical carbon loss has doubled over the past two decades due to excessive forest removal in the tropics. The tropics are an important ecosystem as they store massive amounts of carbon in their woody vegetation and soil -- but they have suffered from extensive forest clearance since 2001. The researchers analyzed the gross forest carbon loss associated with forest removal in the tropics during the 21st century.
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Study identifies new protection mechanism in breast cancer
Researchers have identified a protein that protects against breast tumor growth and that can be linked to a better prognosis in breast cancer patients. The results may contribute to the development of new therapies for difficult-to-treat forms of breast cancer.
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100g of cranberries a day improves cardiovascular health, study finds
A new clinical trial found daily consumption of cranberries for one month improved cardiovascular function in healthy men.
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Switching social identities happens seamlessly
People can switch seamlessly between different social identities, new research shows. Each person has multiple social identities, such as: employee, parent, young person, friend or even fan of a particular sports team.
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100g of cranberries a day improves cardiovascular health, study finds
A new clinical trial found daily consumption of cranberries for one month improved cardiovascular function in healthy men.
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Monday, March 21, 2022
Identifying toxic materials in water with machine learning
Waste materials from oil sands extraction, stored in tailings ponds, can pose a risk to the natural habitat and neighboring communities when they leach into groundwater and surface ecosystems. Until now, the challenge for the oil sands industry is that the proper analysis of toxic waste materials has been difficult to achieve without complex and lengthy testing. And there's a backlog. For example, in Alberta alone, there are an estimated 1.4 billion cubic meters of fluid tailings.
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Taste, temperature and pain sensations are neurologically linked
Biologists have found that the brain categorizes taste, temperature and pain-related sensations in a common region of the brain and that the brain also groups these sensations together as either pleasant or aversive, potentially offering new insights into how scientists might better understand the body's response to and treatment of pain.
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Sunday, March 20, 2022
Saturday, March 19, 2022
Friday, March 18, 2022
Could we make cars out of petroleum residue?
Researchers have developed a way to make lightweight fibers, for possible use in the bodies of cars, out of an ultracheap feedstock: the waste material from the refining of petroleum.
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Antabuse may help revive vision in people with progressive blinding disorders
Animal and cell studies show that as retinal cells die in degenerative eye diseases, they make other cells hyperactive, creating noise that further obscures vision. Tests to prove this in humans are hard to conduct, however. Antabuse, an approved drug used to wean people off alcohol, should tamp down this hyperactivity and conclusively show whether hyperactivity plays a role in humans, potentially driving work to find better drugs to help those with progressive vision loss.
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Piezo1 possible key to supporting muscle regeneration in Duchenne Muscular Dystrophy
Tracing the impact of a single protein, Piezo1, researchers found that restoring it in muscles affected by Duchenne muscular dystrophy could improve their ability to heal efficiently.
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When the brain sees a familiar face
Researchers have uncovered new information about how the area of the brain responsible for memory is triggered when the eyes come to rest on a face versus another object or image.
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Youngest brain tumor patients have significantly poorer outcomes than older pediatric patients
A researcher has found, through extensive data analysis, that the youngest patients with brain tumors -- those ages birth to 3 months -- have about half the five-year survival rate as children ages 1 to 19.
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Lung tissue from the lab
An international research team has found a simple method for growing lung tissue in the lab. These organoids could be used in diagnosis, drug development, and fundamental research. Laboratory studies of lung tissue usually require the removal of large amounts of human or animal tissue. Now scientists have generated tiny quantities of lung tissue, so-called organoids, from just a few body cells in the lab. The tissue forms a three-dimensional structure as it develops, complete with the tiny hairs on the surface typical of lung tissue. These organoids can play an important part in future research on lung diseases, drug development, or personalized medicine.
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New strategy reduces brain damage in Alzheimer’s and related disorders, in mice
Alzheimer's disease is the most common and best known of the tauopathies, a set of neurodegenerative brain diseases caused by toxic tangles of the protein tau. A study has now shown that targeting astrocytes -- an inflammatory cell in the brain -- reduces tau-related brain damage and inflammation in mice.
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Thursday, March 17, 2022
Long-suspected turbocharger for memory found in brain cells of mice
Scientists have long known that learning requires the flow of calcium into and out of brain cells. But researchers have now discovered that floods of calcium originating from within neurons can also boost learning. The finding emerged from studies of how mice remember new places they explore.
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Engineering an 'invisible cloak' for bacteria to deliver drugs to tumors
Researchers have genetically engineered a microbial encapsulation system for therapeutic bacteria that can hide them from immune systems, enabling them to reach tumors more effectively and kill cancer cells in mice.
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Engineering an 'invisible cloak' for bacteria to deliver drugs to tumors
Researchers have genetically engineered a microbial encapsulation system for therapeutic bacteria that can hide them from immune systems, enabling them to reach tumors more effectively and kill cancer cells in mice.
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In U.S., alcohol use disorder linked to 232 million missed workdays annually
Researchers have found that people with severe alcohol use disorder miss more than double the number of workdays missed by individuals without alcohol use disorder.
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Scientists discover why women are more resistant to nonalcoholic fatty liver disease than men
Nonalcoholic fatty liver disease (NAFLD) is one of the leading causes of death worldwide. However, why premenopausal women are more resistant to NAFLD than men is currently unknown. Now, scientists demonstrate, through sex-balanced experiments on mice, that the female liver produces higher levels of a protein that has a protective effect against NAFLD. Their findings could lead to new therapeutic strategies for treating NAFLD.
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AI provides accurate breast density classification
An artificial intelligence (AI) tool can accurately and consistently classify breast density on mammograms, according to a new study.
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Researchers put a spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumor. Researchers are now on a method to detect these cells.
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Delta breakthrough infection generates broad neutralizing antibody response in double vaccinated individuals
A delta breakthrough infection generates a potent and broad neutralizing antibody response to SARS-CoV-2 in double vaccinated individuals, according to new research.
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Wednesday, March 16, 2022
How inland and coastal waterways influence climate
Most global carbon-budgeting efforts assume a linear flow of water from the land to the sea, which ignores the complex interplay between streams, rivers, lakes, groundwater, estuaries, mangroves and more. Climate scientists now detail how carbon is stored and transported through the intricacy of inland and coastal waterways. The work has significant implications for enforcing the carbon calculations that are part of international climate accords.
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How gut microbes work to tame intestinal inflammation
Bile acids, well known for their role in dissolving fats and vitamins, are also important players in gut immunity and inflammation because they regulate the activity of key immune cells linked to a range of inflammatory bowel conditions, such as ulcerative colitis and Crohn's disease, according to new research.
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New flow battery stores power in simple organic compound
The intermittent supply of green electricity requires large-scale storage to keep our power grids stable. Since normal batteries do not scale very well, the idea of using flow batteries, which store electricity in a fluid is attractive. Scientists have designed a flow battery electrolyte that is cheaper and is based on an organic compound, rather than a metal.
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How gut microbes work to tame intestinal inflammation
Bile acids, well known for their role in dissolving fats and vitamins, are also important players in gut immunity and inflammation because they regulate the activity of key immune cells linked to a range of inflammatory bowel conditions, such as ulcerative colitis and Crohn's disease, according to new research.
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Longer, more intense allergy seasons could result from climate change
Allergy seasons are likely to become longer and grow more intense as a result of increasing temperatures caused by humanmade climate change, according to new research.
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Longer, more intense allergy seasons could result from climate change
Allergy seasons are likely to become longer and grow more intense as a result of increasing temperatures caused by humanmade climate change, according to new research.
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Tuesday, March 15, 2022
Vaccine protects against 'tough cookie' parasite found in the Americas
The parasites that cause a disfiguring skin disease affecting about 12 million people globally may have met their match in vaccines developed using CRISPR gene-editing technology, new research suggests.
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When it comes to sleep, it’s quality over quantity
Some people are gifted with genes that pack the benefits of slumber into an efficient time window, keeping them peppy on only four or six hours of sleep a night. In addition, the scientists said, these 'elite sleepers' show psychological resilience and resistance to neurodegenerative conditions that may point the way to fending off neurological disease.
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Making green energy greener: Researchers propose method for wind turbine blades' recycling
Wind turbine blades made from glass fiber-reinforced polymer (GFRP) laminate composites can serve for up to 25 years. After that, they end up in landfills which has become a real challenge for the renewable energy industry. Researchers have proposed a method for wind turbine blades' recycling. Using pyrolysis, they broke the composite materials into their constituent parts. According to scientists, the extracted materials can be reused, and the process is virtually waste-free.
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'Long COVID' linked to lasting airways disease
Disease of the small airways in the lungs is a potential long-lasting effect of COVID-19, according to a new study. The study found that small airways disease occurred independently of initial infection severity. The long-term consequences are unknown.
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Elevated inflammation persists in immune cells months after mild COVID-19
There is a lack of understanding as to why some people suffer from long-lasting symptoms after COVID-19 infection. A new study now demonstrates that a certain type of immune cell called macrophages show altered inflammatory and metabolic expression several months after mild COVID-19.
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Monday, March 14, 2022
Sunday, March 13, 2022
Saturday, March 12, 2022
Friday, March 11, 2022
All organisms produce methane
It is well known that methane, a greenhouse gas, is produced by special microorganisms, for example in the intestines of cows, or in rice fields. For some years, scientists had also observed the production of methane in plants and fungi, without finding an explanation. Now researchers have shed light on the underlying mechanism. Their findings suggest that all organisms release methane.
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Links between circadian rhythms, metabolism and addiction
A new study establishes important conceptual connections between the fields of circadian rhythms, metabolism, and addiction. Going beyond current studies on substance use disorders, which focus on the impact of addictive drugs on the brain, this new research highlights an existing connection between specific neurons and peripheral organs.
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Mutations leading to omicron variant did not enable virus to fully escape immune system
People who gained immunity -- either through vaccination or exposure -- against the original strain of SARS-CoV-2, the virus that causes COVID-19, also are likely to have some protection against the pathogen's omicron variant, according to a new study.
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Bacteria on intertidal rockweed across the North Atlantic
Algae such as rockweeds are a fundamental part of marine ecosystems, providing habitat and food to many other marine organisms while also providing ecosystem services like oxygenation of the water. In turn, algae depend on bacteria to maintain their normal shapes and health. New sequencing methods are illuminating the relationships between marine bacteria and marine algae, as demonstrated in research by 15 scientists from countries across the North Atlantic. The published study contributes to the understanding how sensitive important algae are to the changing environment.
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Exercise may treat long COVID-induced diabetes, depression
While no medically recognized treatment exists for long COVID, exercise may break the vicious cycle of inflammation that can lead to developing diabetes and depression months after a person recovers from the virus.
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Thursday, March 10, 2022
Exploring ancient tuberculosis transmission chains
Tuberculosis (TB) is the second most common cause of death worldwide by an infectious pathogen (after Covid-19), but many aspects of its long history with humans remain controversial. Researchers found that ancient TB discovered in archaeological human remains from South America is most closely related to a variant of TB associated today with seals, but surprisingly these cases were found in people who lived nowhere near the coast. This implies that these cases were not the result of direct transmission from seals, and instead one, or more, spillover events were likely to be the primary drivers of human infection.
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More 'losers' than 'winners' among plants in the age of humans
A new analysis spanning more than 86,000 plant species finds that on this human-dominated planet, many more species of plants are poised to 'lose' rather than 'win.' T
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Blood test as possible diagnostic tool for Alzheimer’s disease
A recent study shows promising results for a blood test that could be used to identify Alzheimer's changes in the brain before the onset of any symptoms, which could result in preventative treatments being used before any memory loss.
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Could leaky blood vessels in the brain be a culprit in Alzheimer’s disease?
Researchers report that they found high levels of the protein Fli-1 in the brains of deceased Alzheimer's patients. Blocking Fli-1's action in a mouse model of Alzheimer's disease reversed mental loss and reduced the brain inflammation and amyloid-beta clumping that are hallmarks of Alzheimer's disease. Although clinical translation of this finding is likely years off, the study suggests Fli-1 is a promising therapeutic target for Alzheimer's disease.
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Cutting HFCs to cool the Earth
To have a better chance of holding global warming to 1.5°C, we need to accelerate the phase-down of HFC refrigerants under the Montreal Protocol. This could also reduce pollution and improve energy access.
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Exploring ancient tuberculosis transmission chains
Tuberculosis (TB) is the second most common cause of death worldwide by an infectious pathogen (after Covid-19), but many aspects of its long history with humans remain controversial. Researchers found that ancient TB discovered in archaeological human remains from South America is most closely related to a variant of TB associated today with seals, but surprisingly these cases were found in people who lived nowhere near the coast. This implies that these cases were not the result of direct transmission from seals, and instead one, or more, spillover events were likely to be the primary drivers of human infection.
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Wednesday, March 9, 2022
Innovative solution for thermal energy storage
A new research article features one major challenge overcome through a remarkably simple idea, opening the door to expanded use of PCMs for energy-efficient heating and cooling.
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Targeting dysregulated kappa-opioid receptors reduces working memory deficits in alcohol use disorder
A preclinical study led by a neuroscientist shows that dysregulated kappa-opioid receptors (KORs) in the brain's medial prefrontal cortex region (part of the frontal lobe) contribute to working memory deficits in severe alcohol dependence. The researchers discovered that an antagonist compound used to block KORs alleviated these working memory deficits and may help restore 'normal' executive function needed to make better decisions about alcohol consumption.
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Forget mammoths: These researchers are exploring bringing back the extinct Christmas Island rat
Dinosaurs went extinct 65 million years ago, mammoths 4,000 years ago, and the Christmas Island Rat 119 years ago. Since becoming a popular concept in the 1990s, de-extinction efforts have focused on grand animals with mythical stature, but now a team of paleogeneticists has turned their attention to Rattus macleari, and their findings provide insights into the limitations of de-extinction across all species.
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How the transition to agriculture affects populations in the present day
The transition of human societies from hunter-gatherers to farmers and pastoralists is a more nuanced process than generally thought, according to a new study of peoples living in the highlands of southwest Ethiopia.
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Skin cancer cells use Alzheimer’s protein to sabotage brain's immune defenses
Amyloid beta, a protein known to build-up in the brains of Alzheimer's patients, also helps skin cancer cells thrive when they spread to the brain, a new study finds.
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Tuesday, March 8, 2022
Lower chance of pregnancy and childbirth after IVF with one ovary
Women who have had one ovary surgically removed (unilateral oophorectomy) are less likely to become pregnant after in vitro fertilization and give birth to fewer babies than women with both ovaries. That is according to an extensive meta-analysis.
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The language of the eyes
What is the significance of the sclera of our eyes? A question which researchers have been interested in for some time now. Recently a research team led by a comparative psychologist has succeeded in deciphering the mystery: The white of the eye contributes decisively to the visibility of directions of gaze through its basic color properties.
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Digital toolbox may help diagnose dementia earlier
Detecting cognitive changes early in the onset of dementia would be a game-changer for thousands impacted by the disease and would allow for interventions well before significant brain changes occur. While cognitive function is often measured using paper and pencil tests with scores calculated by the number of correct answers, this number (score) omits a lot of information about the process a person uses to answer a question that might reveal important information about their brain function.
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Unusual partners aid blood vessel growth
Insufficient oxygen to an area like the heart or legs, called hypoxia, is a cue to our bodies to make more blood vessels, and scientists have found some unusual partners are key to making that happen. They've found that two receptors on the surface of those cells come together then dive inside to enable the new growth, called angiogenesis, scientists report.
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Study of rare disease reveals insights on immune system response process
In laboratory experiments involving a class of mutations in people with a rare collection of immune system disorders, researchers say they have uncovered new details about how immune system cells respond to disease-causing bacteria, fungi and viruses such as SARS-CoV-2.
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Protect against aging and age-related disease with the MondoA protein
Researchers have shown that a protein called MondoA can activate the important health-linked process of autophagy, whereby cells are broken down and their components are recycled. MondoA both inhibited a protein called Rubicon and regulated the Prdx3 protein, which maintains the stability of energy-producing mitochondria within cells. Activation of MondoA protected against aging and age-associated kidney injury, indicating its potential as a target for the treatment of aging and age-related diseases.
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Protect against aging and age-related disease with the MondoA protein
Researchers have shown that a protein called MondoA can activate the important health-linked process of autophagy, whereby cells are broken down and their components are recycled. MondoA both inhibited a protein called Rubicon and regulated the Prdx3 protein, which maintains the stability of energy-producing mitochondria within cells. Activation of MondoA protected against aging and age-associated kidney injury, indicating its potential as a target for the treatment of aging and age-related diseases.
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Monday, March 7, 2022
Pig grunts reveal their emotions
We can now decode pigs' emotions. Using thousands of acoustic recordings gathered throughout the lives of pigs, from their births to deaths, an international team of researchers has translated pig grunts into the emotions they appear to express.
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Sunday, March 6, 2022
Saturday, March 5, 2022
New discovery may help reduce side effects of multiple sclerosis drugs
Investigators have discovered how a drug for multiple sclerosis interacts with its targets, a finding that may pave the way for better treatments.
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Friday, March 4, 2022
Artificial intelligence predicts algae potential as alternative energy source
Texas A&M AgriLife Research scientists are using artificial intelligence to set a new world record for producing algae as a reliable, economic source for biofuel that can be used as an alternative fuel source for jet aircraft and other transportation needs.
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New research suggests a causal link between blood group and severe COVID-19
A new study has analysed over 3000 proteins to identify which are causally linked to the development of severe COVID-19. This is the first study to assess such a large number of proteins for their connection to COVID-19. The findings provide insight into potential new targets for approaches to treat and prevent severe COVID-19.
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More alcohol, less brain: Association begins with an average of just one drink a day
Even light-to-moderate drinking is associated with harm to the brain, according to a new study. Researchers analyzed data from more than 36,000 adults that found a link between drinking and reduced brain volume that begins at an average consumption level of less than one alcohol unit a day -- the equivalent of about half a beer -- and rises with each additional drink.
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Cohorting patient care model during pandemic improved patient outcomes, researchers find
Researchers found that, during the extenuating circumstances of an emerging pandemic, grouping patients together in one area or facility was successful in providing high-quality care and containing infectious patients.
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More alcohol, less brain: Association begins with an average of just one drink a day
Even light-to-moderate drinking is associated with harm to the brain, according to a new study. Researchers analyzed data from more than 36,000 adults that found a link between drinking and reduced brain volume that begins at an average consumption level of less than one alcohol unit a day -- the equivalent of about half a beer -- and rises with each additional drink.
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Thursday, March 3, 2022
Mussels' underwater glue inspires synthetic cement
Researchers have used a novel method to replicate mussel-adhesive proteins, creating a stronger glue than the material they set out to mimic.
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Taller adults may be at increased risk for colorectal cancer
A new meta-analysis, or data examination of several independent studies, adds to evidence that taller adults may be more likely than shorter ones to develop colorectal cancer or colon polyps that can later become malignant.
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Weighing up: What’s the bottom line when it comes to weight loss?
When it comes to weight loss, many of us have dabbled in the latest diets. But whether you're cutting carbs or keeping to keto, new research shows that diet trends can cost more than your waistline and leave a hefty hole in your hip pocket.
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Women with irregular periods may be at risk for liver disease
Women with long or irregular periods are known to have a higher risk of type 2 diabetes and heart disease, but researchers found these women may also be at risk for nonalcoholic fatty liver disease (NAFLD).
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Special shell protects Antarctic scallop from ice build-up
Airplane wings that don't ice up or solar cells that generate electricity even in winter - ice-free surfaces are important for many applications. A team of scientists has now studied an Antarctic scallop species that opposes the icing process with the help of its shell surface. Due to their special structure, thin layers of ice adhere poorly and are easily washed away by the flow. The discovery could help in the development of ice-free bionic surfaces in the long term.
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Evidence links e-cigarette use with increased odds of prediabetes
An analysis of data from a large, nationally representative survey of the US population shows that e-cigarette use is associated with increased odds of prediabetes. The findings add important evidence about the health effects of e-cigarettes and can help shape public health best practices.
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Wednesday, March 2, 2022
Early menopause may raise risk of dementia later in life
Compared with women who enter menopause around age 50, women who experience very early menopause (before the age of 40) were found to be 35% more likely to develop some type of dementia later in life, according to a large study of women living in the United Kingdom. Women who entered menopause before age 45 were also 1.3 times more likely to develop dementia before the age of 65. In addition, women who entered menopause later, at age 52 or older, had dementia risk similar to women who entered menopause at the average age for menopause onset which is the age of 50 to 51 years.
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Cerebrospinal fluid may be able to identify aggressive brain tumors in children
It may be possible to identify the presence of an aggressive brain tumor in children by studying their cerebrospinal fluid, according to new research.
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Gene Editing gets safer thanks to redesigned Cas9 protein
Scientists have redesigned a key component of a widely used CRISPR-based gene-editing tool, called Cas9, to be thousands of times less likely to target the wrong stretch of DNA while remaining just as efficient as the original version, making it potentially much safer.
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Virology: Equine hepatitis viruses and hepatitis C
As of today, there is no vaccine against hepatitis C. To improve the search for it, researchers are looking for a so-called surrogate model: an animal that can also suffer from viral hepatitis and whose course of infection allows conclusions about the behavior of the hepatitis C virus in humans. They found what they were looking for in the horse.
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Cocoa does not appear to reduce exercise-related digestive distress
Impressive athleticism was on display during the Winter Olympics, but being at the top of one's game doesn't necessarily protect against digestive distress resulting from exercise. Surprisingly, some people are adding cocoa to their diets to reduce these symptoms. Now, researchers report that long-term daily consumption of cocoa doesn't appear to improve exercise-related digestive issues in male athletes and induces only minimal changes to their gut microbiomes.
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Mucus could explain why SARS-CoV-2 doesn't spread easily from surfaces
Early in the pandemic, many people fastidiously disinfected surfaces because laboratory studies predicted that SARS-CoV-2 could be easily transmitted in this way. Now, researchers have found a possible explanation for why the predictions didn't pan out: Sugar-decorated proteins in mucus could bind to the coronavirus on surfaces, keeping it from infecting cells. The findings could also hint at why some people are more vulnerable to COVID-19 than others.
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We should be eating more insects and using their waste to grow crops, says plant ecologist
Researchers already knew that insects are an excellent source of protein for humans, but they didn't expect to learn that they have such a positive impact on plants. Researchers discuss the benefits of using the waste from insect-as-food-and-feed production to promote sustainable crops.
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Tuesday, March 1, 2022
New epigenetic biomarkers found that potentially predict preterm birth
A signature found in the cheek cells of mothers and fathers of preterm infants may help develop a test to determine whether a pregnancy may end too early. Such a test could help prevent premature births and the many resulting health impacts on infants by alerting medical providers to the need for early intervention measures. In a proof of concept study, researchers documented more than 100 epigenetic biomarkers in mothers of preterm babies that were distinct from mothers of babies carried to term. Fathers had fewer biomarkers but enough to indicate a likely paternal role in preterm birth. They also found that the preterm female babies carried more than 100 of these biomarkers, indicating the propensity to have a preterm baby may be passed down.
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Noble false widow spider captures bats in the attic
Scientists have published the first record of a Noble False Widow spider feeding on a protected species of Pipistrelle bats in the UK. The new study demonstrates that False Widow spiders continue to impact native species.
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Protein protects brain cells most impacted by glaucoma
A ubiquitous protein called sigma 1 receptor, which is known to protect cells from stress, appears key to the function and survival of the neurons most impacted by glaucoma, scientists report.
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Why exercise gets harder the less you do
Doing less exercise could deactivate a vital protein in the body, causing further inactivity and making exercise more difficult, new research suggests. Deactivating the Piezo1 protein, a blood flow sensor, reduces the density of capillaries carrying blood to the muscles. This restricted blood flow means activity becomes more difficult and can lead to a reduction in how much exercise is possible. This helps to explain the biology of why exercise becomes harder the less you do.
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The root of it: Understanding molecular basis of lateral root development in rice
The ability of rice plants to modify their root systems to adapt to the surrounding soil water conditions is a great example of a phenomenon called phenotype plasticity. However, the exact mechanism behind this remained unknown. Now researchers have determined the role of two WUSCHEL-related homeobox (WOX) genes in controlling the root primordium size in lateral roots.
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