Saturday, April 30, 2022
Friday, April 29, 2022
All cells are important: A roadmap to characterize lymphoma stroma
Researchers identify gene expression signatures in different types of lymph nodes cells that play an active role in the development of lymphomas.
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New details behind the body's response to tuberculosis could lead to a more effective vaccine
In a person with active tuberculosis, immune activity can promote bacterial clearance, but in some situations, bacteria persist and grow. New research in an animal model of tuberculosis reveals which cellular and molecular features are associated with these different scenarios. Developing a vaccine that targets one or more of these features may effectively combat tuberculosis, which remains a major global health threat.
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Scientists illuminate mechanism of common drug target
Using advanced imaging methods, researchers have gained insight into how a common target of drugs sends cellular signals, a finding that may lead to better and more precise therapeutics.
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An epigenetic cause of miscarriages is identified and cured in mice
Researchers have discovered a gene responsible for prenatal death when critical epigenetic instructions are missing from egg cells. The study shows that in mice, failed epigenetic suppression of an X-chromosome gene called Xist leads to miscarriage and developmental abnormalities. Forced suppression of maternal Xist rescued the failed miscarriages.
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Thursday, April 28, 2022
How to balance economic development goals with environmental conservation
An international study gives fast-growing nations a simple, inexpensive guide to inform planning and decision-making to help balance economic development goals with environmental conservation and human well-being.
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Decreased genetic diversity in immune system could impact endangered toad survival
A new study examines immune system diversity in the critically endangered Wyoming toad and finds that genetic bottlenecks could impact a species' ability to respond to new pathogens. The findings could inform captive breeding strategies for endangered animal populations.
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Selection bias may lead to underestimation of risk of CTE in former football players
Researchers have been studying chronic traumatic encephalopathy (CTE) and while much has been learned, diagnosing the disease still needs to be done post-mortem on autopsied brains donated to a brain bank. One criticism of the research is that brain bank study results have a selection bias because they are based on a subset of players most affected by CTE, and therefore not representative of the population of football players. Now a novel study by researchers from BUSM and Boston University School of Public Health (BUSPH) provides further evidence suggesting a dose-response relationship between football and CTE even after adjusting for selection bias.
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From blurry to bright: AI tech helps researchers peer into the brains of mice
Biomedical engineers have developed an artificial intelligence (AI) training strategy to capture images of mouse brain cells in action. The researchers say the AI system, in concert with specialized ultra-small microscopes, make it possible to find precisely where and when cells are activated during movement, learning and memory.
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From blurry to bright: AI tech helps researchers peer into the brains of mice
Biomedical engineers have developed an artificial intelligence (AI) training strategy to capture images of mouse brain cells in action. The researchers say the AI system, in concert with specialized ultra-small microscopes, make it possible to find precisely where and when cells are activated during movement, learning and memory.
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New study identifies genetic changes in patients who progress to esophageal cancer
A scientific team who studies a precancerous condition of the esophagus (called Barrett's esophagus or BE) are working to answer how to see genetic changes in cells before they turn cancerous. The team revealed that DNA changes in BE cells that presage esophageal cancer can be spotted years before cancer develops.
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Wednesday, April 27, 2022
How one inflammatory disorder exacerbates another
People with severe gum disease are at a higher risk of other inflammatory conditions, such as heart disease and arthritis, and the reverse is true as well. New research unpacks the mechanism underlying this association, demonstrating in mice that a susceptibility to arthritis can be transmitted by a bone marrow transplant if the donor has gum inflammation.
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RNA binding proteins help T cells pick their weapons before battle
Researchers have identified key drivers of T cell development which promote resilience to influenza virus infection.
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Japanese population projected to live longer without dementia
A new microsimulation projects that over the next 20 years, Japanese people will live longer without dementia, but older women with a less than high school education will benefit less than men.
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E. coli bacteria exploits Crohn's disease inflammation
A multi-year study of the role of E. coli gut bacteria in Crohn's disease finds that intestinal inflammation liberates chemicals that nourish the bacteria's growth and promotes their ability to cause inflammation.
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Monitoring and evaluation of climate adaptation conservation initiatives
A new study offers pathways to improve monitoring and evaluation (M&E) of climate-informed conservation while revealing how practitioners are currently monitoring conservation adaptation projects.
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Bat box design, placement matter for energy balance in endangered bats
New research looks at the effect of bat box design and placement on the energetic balance of endangered Indiana bats.
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Neuronal plasticity in chronic pain-induced anxiety revealed
Researchers have shown how chronic pain leads to maladaptive anxiety in mice, with implications for treatment of chronic pain-related psychiatric disorders in humans.
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Tuesday, April 26, 2022
Micronutrients (vitamins + minerals) show benefit for children with ADHD and emotional dysregulation
A study reports that children with ADHD and emotional dysregulation randomized to take a micronutrient formula were three times more likely to show symptomatic improvement on blinded clinician ratings, compared to those in the placebo group (54% versus 18%). The micronutrient formula, consisting of all known vitamins and essential minerals, was administered for eight weeks.
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A new treatment reduces inflammation in multiple sclerosis mice models
Researchers managed to reduce chronic inflammation associated with multiple sclerosis in mice thanks to the administration of a type of lipid that mediates inflammation.
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Immersive VR: Empowering kids to survive in fire, flood, and war
When you live in the driest State in the driest country in the world, bushfires are an unfortunate, and all-too-regular part of life. Learning how to survive such emergencies is important for all people, but especially for our youngest citizens.
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Protecting species for the good of global climate
Until now, measures to protect climate and biodiversity have often been developed in parallel. However, this is now considered outdated because many approaches can protect both climate and biodiversity. Scientists have now assessed the role of the potential future global biodiversity targets (Post-2020 Action Targets for 2030) for climate protection and found that about two thirds of these targets can also help to slow climate change.
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Speed thrills but kills: Major highway in India of particular concern to reptiles and amphibians
The National Highway 715, which passes through the Kaziranga National Park in Northeast India, is notorious for its roadkill. With protected habitats on both sides of the road, many animals cross it on a daily basis to feed and breed.
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Pathogens can hitch a ride on plastic to reach the sea
Microplastics are a pathway for pathogens on land to reach the ocean, with likely consequences for human and wildlife health, according to a new study. This study connects microplastic pollution in the ocean with land-based, diseases-carrying pathogens. The study, published April 26 in the journal Scientific Reports, is the first to connect microplastics in the ocean with land-based pathogens
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Boys are more demanding than girls before they are born, according to scientists
Finding out the sex of a baby during pregnancy could lead to better life chances, a new study has discovered. Male baby pregnancies are more likely to result in complications, possibly because they grow faster in the womb and require more nutrients and oxygen than supplied by the mother through the placenta -- the temporary organ that attaches to the wall of the uterus during pregnancy to help the fetus grow and develop.
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Monday, April 25, 2022
Scientists have discovered how bloodworms make their unique copper teeth
Bloodworms are known for their unusual fang-like jaws, which are made of protein, melanin, and concentrations of copper not found elsewhere in the animal kingdom. Scientists have observed how these worms use copper harvested from marine sediments to form their jaws, and the process may be even more unusual than the teeth themselves.
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A new era of mitochondrial genome editing has begun
A new era of mitochondrial genome editing has begun. Scientists successfully achieve A to G base conversion, the final missing piece of the puzzle in gene-editing technology.
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A new era of mitochondrial genome editing has begun
A new era of mitochondrial genome editing has begun. Scientists successfully achieve A to G base conversion, the final missing piece of the puzzle in gene-editing technology.
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Sunday, April 24, 2022
Saturday, April 23, 2022
Friday, April 22, 2022
Federal research funding has positive 'ripple effects'
Federal funding for biomedical research has a 'ripple effect' of stimulating new studies even beyond the original purposes of a grant and may provide unexpected benefits, a new study suggests.
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Federal research funding has positive 'ripple effects'
Federal funding for biomedical research has a 'ripple effect' of stimulating new studies even beyond the original purposes of a grant and may provide unexpected benefits, a new study suggests.
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Breakthrough in estimating fossil fuel carbon dioxide emissions
Scientists have made a major breakthrough in detecting changes in fossil fuel carbon dioxide emissions more quickly and frequently.
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An ocean in your brain: Interacting brain waves key to how we process information
For years, the brain has been thought of as a biological computer that processes information through traditional circuits, whereby data zips straight from one cell to another. While that model is still accurate, a new study shows that there's also a second, very different way that the brain parses information: through the interactions of waves of neural activity. The findings help researchers better understand how the brain processes information.
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Thursday, April 21, 2022
Expect to see more squid and less sockeye salmon on 'climate changed' menus
Vancouver seafood lovers may see more Humboldt squid but less sockeye salmon on restaurant menus in the near future due to climate change. That's according to a new study which examined 362 Vancouver restaurant menus from four time periods, spanning 1880 to 2021.
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Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment
Experts have developed a ground-breaking software, which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.
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Brains and brawn helped crows and ravens take over the world
Crows and ravens have great flying ability, which allows them to gain access to new places more easily. While these skills were key to their success, new research also shows that big bodies and big brains played an important role in helping crows and ravens survive in the new climates they occupied.
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Spatial distribution of pores helps determine where carbon is stored in the soil
Soils store more carbon than all the vegetation on the Earth's surface. However, there are still many unanswered questions about precisely which processes favor accumulation in the soil. Soil scientists have now developed a new method to show where and under what conditions carbon is stored f in the soil. It turns out, it is primarily the network of soil pores that controls the spatial distribution of carbon.
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Scientists use machine learning to identify antibiotic resistant bacteria that can spread between animals, humans and the environment
Experts have developed a ground-breaking software, which combines DNA sequencing and machine learning to help them find where, and to what extent, antibiotic resistant bacteria is being transmitted between humans, animals and the environment.
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For cooperative teams, modesty leaves the best impression
People may forgo displaying luxury brands and other signals of status when they want to convince others that they will collaborate well with a team, as people who signal their wealth and social status could be perceived as uncooperative, according to new research.
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People with diabetes and cognitive decline may be at higher risk for heart disease
People with type 2 diabetes who have cognitive impairment could be at greater risk for stroke, heart attack or death than other individuals with diabetes, according to a new study.
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Wednesday, April 20, 2022
Warming climate and agriculture halve insect populations in some areas
Climate change and intensive agricultural land use have already been responsible for a 49% reduction in the number of insects in the most impacted parts of the world, finds a new study.
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Women's earnings drop after childbirth, study finds
When U.S. couples have their first child, mothers' earnings still drop substantially relative to fathers', and new research demonstrates the stubborn, decades-old pattern isn't changing despite broad increases in other aspects of gender equality.
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Scientists identify potential new 'soldier' for cancer immunotherapy
The new cells, which the scientists have dubbed killer innate-like T cells, differ in several notable ways from the conventional target of many immunotherapies.
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Everyday plastic products release trillions of microscopic particles into water
Plastics surround us, whether it's the grocery bags we use at the supermarket or household items such as shampoo and detergent bottles. Plastics don't exist only as large objects, but also as microscopic particles that are released from these larger products. These microscopic plastics can end up in the environment, and they can be ingested into our bodies.
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In the race to solve Alzheimer's disease, scientists find more needles in the haystack
The International Genomics of Alzheimer's Project (IGAP) analyzed millions of genetic variants to come up with the latest listing of 75 variations associated with Alzheimer's disease.
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Whole-brain preclinical study illuminates how epileptic seizures originate
New evidence from a zebrafish model of epilepsy may help resolve a debate into how seizures originate, according to investigators. The findings may also be useful in the discovery and development of future epilepsy drugs.
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How do our eyes stay focused on what we reach for?
Keeping our eyes focused on what we reach for, whether it be an item at the grocery store or a ground ball on the baseball field, may appear seamless, but, in fact, is due to a complex neurological process involving intricate timing and coordination. Researchers now shed additional light on the machinations that ensure we don't look away from where we are reaching.
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Tuesday, April 19, 2022
Bioengineers visualize fat storage in fruit flies
A new visualization technique is being used to untangle often discussed, yet mysterious, links between diet and things like obesity, diabetes and aging.
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Bioengineers visualize fat storage in fruit flies
A new visualization technique is being used to untangle often discussed, yet mysterious, links between diet and things like obesity, diabetes and aging.
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Mental illness associated with increased death from cardiovascular disease
Compared to the general population, people with severe mental illness, including schizophrenia, have higher levels of cardiovascular-related mortality, and that association has become stronger over recent decades, according to a new study.
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New research predicts the disappearance of Olympic Peninsula glaciers
By 2070, the glaciers on the Olympic Peninsula, in Washington State, will have largely disappeared, according to a new study. Although some glaciers will probably remain -- albeit as tiny shells of their former selves. Since about 1900 the region has lost half of its glacier area and since 1980, 35 glaciers and 16 perennial snowfields have disappeared.
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Portable, point-of-care COVID-19 test discerns alpha variant from earlier strains
A point-of-care COVID-19 test developed by researchers can now detect and differentiate the alpha variant of the SARS-CoV-2 virus from earlier strains in saliva samples.
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Portable, point-of-care COVID-19 test discerns alpha variant from earlier strains
A point-of-care COVID-19 test developed by researchers can now detect and differentiate the alpha variant of the SARS-CoV-2 virus from earlier strains in saliva samples.
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Cancer burden facing Asian Americans partly caused by racism, experts say
Racism facing Asian Americans is compounding existing cancer inequities. They are the first U.S. population group to experience cancer as the leading cause of death. A commentary outlines the factors contributing to this.
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Monday, April 18, 2022
Sunday, April 17, 2022
Rilzabrutinib for blood disorder shows promise in phase 1--2 clinical trial
In an international phase 1--2 clinical trial of patients with immune thrombocytopenia, an oral investigational drug called rilzabrutinib was active and associated with only low-level toxic effects at all dose levels.
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Saturday, April 16, 2022
Body's response to different strains of tuberculosis could affect transmission
Two strains of the bacterium causing tuberculosis have only minor genetic differences but attack the lungs in completely different fashion, according to researchers.
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Friday, April 15, 2022
A key brain region for substance use disorders now has a searchable atlas of distinct cell populations
In a work of systematic biology that advances the field, researchers have identified 16 distinct cell populations in a complex area of the midbrain called the ventral tegmental area, or VTA. The VTA is important for its role in the dopamine neurotransmission involved in reward-directed behavior. Substance use disorders involve dysregulation of these reward circuits, leading to repeated drug-seeking despite adverse consequences.
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DIY digital archaeology: New methods for visualizing small objects and artifacts
A new article presents step-by-step protocols for creating publishable 2D and 3D visualizations. The techniques will allow anyone to produce high-quality images and models with minimal effort and cost.
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Changes in vegetation shaped global temperatures over last 10,000 years
Follow the pollen. Records from past plant life tell the real story of global temperatures. Warmer temperatures brought plants -- and then came even warmer temperatures, according to new model simulations.
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A new toolkit to engineer safe and efficient therapeutic cells
Researchers undertook a systematic analysis of the molecular building blocks used to engineer therapeutic cells. Their work resulted in a comprehensive rule book for the design of therapeutic cells with improved specificity and safety, and for the eventual customization of cell-based therapies.
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Research could enable assembly line synthesis of prevalent amine-containing drugs
A research team has discovered a new chemical reaction that provides a simple, rapid way of making tertiary amines -- swinging the door wide open to the discovery of new medicinal compounds.
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From cell fat to cell fate
A cell's production of fat molecules can be a key factor in determining what that cell will become.
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Methionine restriction may improve aggressive brain cancer prognosis in children
Deadly brain cancers called diffuse midline gliomas are uniquely dependent on methionine, an amino acid abundant in legumes and poultry.
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Human fetuses evolved to slow shoulder growth for easier delivery
The growth of human shoulders slows down just before birth and speeds up thereafter; this alleviates the problem of shoulder dystocia. Computed tomography was used to obtain cross-sectional representations of the clavicle in humans, chimpanzees, and Japanese macaques; the researchers then looked at different shoulder-width to birth-risk correlations between humans and the two other primates.
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Thursday, April 14, 2022
Seafloor spreading has been slowing down
A new global analysis of the last 19 million years of seafloor spreading rates found they have been slowing down. Geologists want to know why the seafloor is getting sluggish.
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Factors including extreme winds, topography and vegetation influenced the severity of burns from Oregon's devastating 2020 megafires
In a new study examining burn patterns from the 2020 Labor Day fires, researchers studied the influence of weather, topography, vegetation and other factors on burn severity in areas where the fires killed more than 75% of the trees. Their research confirms that extreme winds over the Labor Day holiday were the primary driver of the destructive force of the fires yet demonstrates how forest vegetation structure (e.g., canopy height, the age of trees, etc.) and topography played a significant role in burn severity patterns.
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Exposure assessment for Deepwater Horizon oil spill: Health outcomes
Mathematicians have developed statistical methods that lay the framework for the crucial first step of determining whether there are any linkages between exposures and health outcomes from the 2010 Deepwater Horizon oil spill, which is considered the largest marine oil spill in the history of the U.S.
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Could releasing ‘handbrake’ immune cells help supercharge immunity?
Researchers have found a way to supercharge immune cells that could enable them to clear disease and infections faster
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Exercise during pregnancy reduces the risk of Type-2 Diabetes in offspring
Exercising during pregnancy bestows a wealth of benefits upon a child. New research suggests that exercise may also help reduce the offspring's chances of getting type 2 diabetes. Researchers uncovered how SOD3, a key protein released by the placenta after exercise, improves the metabolic health of offspring and negates the impacts of maternal obesity and poor diets.
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Management researchers prescribe possible remedy in opioid misuse
A team of researchers developed a framework that may help clinicians objectively identify and estimate harms and benefits of opioid use for pain management.
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About 1 in 4 adults has an often-missed liver disorder linked to higher heart disease risk
It is estimated that about one in four adults worldwide has an abnormal build-up of fat in the liver, called non-alcoholic fatty liver disease (NAFLD). NAFLD can lead to permanent liver damage, and heart disease is the leading cause of death in people with fatty liver disease. Because NAFLD is often missed in routine medical screening, the new scientific statement raises awareness and understanding about its link to heart disease and to outline how to prevent and diagnose the condition.
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Scientists identify novel approach to preventing seizures
Scientists have announced a significant advance in our understanding of epilepsy, as they have identified a potential method of preventing damaging seizure activity. Brain cells are nourished by an intricate network of capillaries that forms the so-called blood-brain barrier (BBB). Fundamentally, it is disruption to the integrity of these capillaries and the BBB that a group of scientists believe is a key driver of seizure activity in humans. Promisingly though, their new research shows that restoring that integrity can prevent seizures.
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Wednesday, April 13, 2022
Layered controls can significantly curb exposure to COVID-19
Using a new computational model that simulates the life cycle of pathogen-laden particles, researchers found that a combination of distancing of six feet, universal mask-wearing, and increased room ventilation could reduce the risk of infection by more than 98 percent in more than 95 percent of scenarios studied.
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Treatment prevents hypoglycemia in children with hyperinsulinism
Researchers have shown that a targeted treatment they developed is effective at controlling blood sugar in patients with hyperinsulinism (HI), a genetic disease in which the pancreas produces too much insulin. The findings provide further evidence that the treatment could prevent hypoglycemia in patients with HI and may preclude the need for a full removal of their pancreas, a current standard treatment for severe diffuse HI.
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Busy mothers did less breastfeeding in 19th century Netherlands
A 19th century rural Dutch village had unusually low rates of breastfeeding, likely because mothers were busy working, according to a new study.
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Vegan diets for dogs may be linked with better health, and could be less hazardous, than meat-based diets
A survey study of the guardians of more than 2,500 dogs explored links between dog diet and health outcomes, suggesting that nutritionally sound vegan diets may be healthier and less hazardous than conventional or raw meat-based diets.
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Discovery of wheat’s clustered chemical defenses creates new avenues for research
Research collaboration has helps to explain the chemical defenses that protect wheat plants against disease.
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Blood type may offer insights into risk of blood clot in people with cancer
A new study suggests that people with cancer and non-O blood types, such as types A, B, and AB, face an increased risk of developing venous thromboembolism (VTE), or blood clots in the veins, three months after their initial diagnosis. Scientists have long strived to understand the risk factors for VTE, the leading cause of preventable hospital deaths in the United States. Existing assessments use factors like tumor or cancer type to detect those at high risk of VTE. Yet, many patients without these diagnoses still develop life-threatening blood clots but go unidentified.
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Tuesday, April 12, 2022
Long-term in vivo imaging technique developed to better understand and treat spinal cord injury
A research team has developed an innovative technology for in vivo imaging of the important biological processes involved in the injury and repair of spinal cords, paving the way for a better understanding of the pathology and potential treatment of spinal cord injury (SCI).
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Bacteria generate electricity from methane
Generating power while purifying the environment of greenhouse gases should be achievable using bacteria. Microbiologists have demonstrated that it is possible to make methane-consuming bacteria generate power in the lab.
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Microscaffolds: A new strategy in tissue engineering
A new strategy in tissue engineering has been developed: Tiny spherical microscaffolds are created in a high precision 3D printer. They are cultivated with living cells and then assembled. The cells keep multiplying, creating a tissue, the scaffolds are eventually degraded.
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Microscaffolds: A new strategy in tissue engineering
A new strategy in tissue engineering has been developed: Tiny spherical microscaffolds are created in a high precision 3D printer. They are cultivated with living cells and then assembled. The cells keep multiplying, creating a tissue, the scaffolds are eventually degraded.
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Machine learning predicts conduct disorder in kids
Conduct disorder (CD) is a common yet complex psychiatric disorder featuring aggressive and destructive behavior. Factors contributing to the development of CD span biological, psychological, and social domains. Researchers have identified a myriad of risk factors that could help predict CD, but they are often considered in isolation. Now, a new study uses a machine-learning approach for the first time to assess risk factors across all three domains in combination and predict later development of CD with high accuracy.
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Discovery reveals new way to inhibit key cancer driver, other mutated genes
Scientists have discovered a new way to inhibit the most commonly mutated gene underlying human tumor growth, paving the way for new treatments for cancer and a host of other diseases.
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Monday, April 11, 2022
Smoking increased in those trying to quit during COVID-19, study shows
A study showed statistically significant and potentially clinically important differences between those who increased and decreased tobacco use during the pandemic. Among current smokers, 28.2 percent reported increased tobacco use, 17.3 percent reported decreased tobacco use and 54.5 percent reported no change. In addition, there were no reports of relapse among former smokers.
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Even in a virtual classroom, preschoolers can gain reading skills
A new study finds that children can develop key reading skills in a virtual classroom with other students.
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COVID-19 vaccine protects patients with inflammatory bowel disease from SARS-CoV-2
COVID-19 vaccines taken by people with inflammatory bowel disease (IBD), which affects millions worldwide, safely and effectively protects them from the SARS-Cov-2 virus, a study finds.
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Time-lapse images as the living brain responds to experiences
Researchers use manganese-enhanced magnetic resonance imaging to capture time-lapse images of the living brain.
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Innovative technology will use smart sensors to ensure vaccine safety
A new study enables developers to determine vaccine safety via smart sensors that measure objective physiological parameters.
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New transistor could cut 5% from world’s digital energy budget
A new spin on one of the 20th century's smallest but grandest inventions, the transistor, could help feed the world's ever-growing appetite for digital memory while slicing up to 5% of the energy from its power-hungry diet.
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SARS-CoV-2: Neutralization of BA.1 and BA.2 by therapeutic monoclonal antibodies
Scientists studied the sensitivity of Omicron BA.1 and BA.2 to nine monoclonal antibodies, some of which are used in pre-exposure prophylaxis in immunocompromised individuals. The scientists showed a loss of neutralizing activity against BA.1 and BA.2 in people treated with two antibody cocktails.
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Sunday, April 10, 2022
Melting ice caps may not shut down ocean current
Most simulations of our climate's future may be overly sensitive to Arctic ice melt as a cause of abrupt changes in ocean circulation, according to new research.
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Researchers adapt technology made for astronomical observations to biomedical imaging
Researchers have captured images of multiple radionuclides in mice using astronomy technology.
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Researchers describe a three-meter-long Mesozoic marine reptile named Baisesaurus robustus
Researchers from China and Canada report a new large early ichthyosauromorph, named Baisesaurus robustus, from the southwest of China, extending the known geographic distribution of this group.
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Saturday, April 9, 2022
Friday, April 8, 2022
How T cell-derived interleukin-22 promotes antibacterial defense of colonic crypts
Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea. Such pathogens pose significant risks to human health and cause infant death in developing countries. A new study shows how two types of immune cells -- one a part of the innate immune system and the other a part of the adaptive immune system -- play distinct and indispensable roles to defend that barrier.
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Air pollution responsible for 180,000 excess deaths in tropical cities
Around 180,000 avoidable deaths over 14 years in fast-growing tropical cities were caused by a rapid rise in emerging air pollution, a study has revealed.
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CRISPR gene editing reveals biological mechanism behind common blood disorder
Researchers have used CRISPR gene editing -- a type of 'molecular scissors' -- to understand how deletions in one area of the genome can affect the expression of nearby genes. The work will help researchers investigate new therapeutic approaches for one of the world's most devastating genetic blood disorders -- sickle cell disease. Asymptomatic sickle cell disease patients actually lack a tiny part of the genome, scientists have shown.
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Key to success of drug-resistant bacteria
Researchers have uncovered how Gram-negative bacteria -- which cause a variety of drug-resistant infections -- build their protective outer layer, which could lead to more effective treatments.
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Dengue detection smartphone tech shows new hope for low-cost diagnostics
Accurate home testing could be used for a wider range of illnesses, as new research shows the capability of smartphone-powered tests for Dengue Fever.
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Thursday, April 7, 2022
Wireless, high-speed, low-power communications for implantable devices
Implantable bioelectronics are now often key in assisting or monitoring the heart, brain, and other vital organs, but they often lack a safe, reliable way of transmitting their data to doctors. Now researchers have invented a way to augment implantable bioelectronics with simple, high-speed, low-power wireless data links using the body's naturally present ions.
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Amazon rainforest foliage gases affect the Earth’s atmosphere
Researchers have uncovered a plant-derived process that leads to the formation of aerosol particles over the Amazon rainforest and potentially other forested parts of the world.
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Study discovers molecular properties of lung surfactants that could lead to better treatments for respiratory illnesses
A research team analyzed the fundamental properties and structures of the naturally occurring substances that help human lungs expand and contract, providing insight into how the substances help us breathe.
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Antibiotic and antiretroviral drug effects on breast milk are explored for mothers living with HIV
Infants carry a vast assemblage of bacteria, viruses and fungi in their guts. Combined, these microbes make up a complex ecology known as the gut microbiome, which plays a major role in health and disease throughout life. The initial source of these billions of microbes is the mother's breast milk. Scientists have now used next-generation sequencing to investigate the breast milk microbiome from HIV positive women in Kenya.
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Wastewater provides a planet-wide laboratory for the study of human health
New research highlights a technique known as Wastewater-based Epidemiology (WBE), in which samples of municipal wastewater can be used as a diagnostic tool to explore a surprisingly broad range of community-wide health indices.
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Wednesday, April 6, 2022
Like college roommates, vampire bats bond when randomly paired
Social bonding between randomly assigned college roommates is not only a human phenomenon, a new study on vampire bats suggests. Vampire bat pairs that were forced to live together for only one week sustained their friendly relationships for more than two months after they were released into a bigger bat community.
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Century-old malaria parasite puzzle solved as ape origin traced
Scientists have solved a 100-year-old mystery about the evolutionary links between malaria parasites that infect humans and chimpanzees.
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Century-old malaria parasite puzzle solved as ape origin traced
Scientists have solved a 100-year-old mystery about the evolutionary links between malaria parasites that infect humans and chimpanzees.
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New link between greenhouse gasses and sea level rise
Researchers have used advanced ocean modelling techniques to reveal how greenhouse gas emissions contribute to warmer oceans and resulting melting of the West Antarctic Ice Sheet.
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Simulations explain Greenland’s slower summer warming
Climate changes in the tropical Pacific have temporarily put the brakes on rapid warming and ice melting in Greenland.
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Neolithic made us taller and more intelligent but more prone to heart disease
After the Neolithic, European populations showed an increase in height and intelligence, reduced skin pigmentation and increased risk of cardiovascular disease due to genetic changes that lowered concentrations of 'good' HDL cholesterol. The changes reflect ongoing evolutionary processes in humans and highlight the impact the Neolithic revolution had on our lifestyle and health. Research of these past events offers interesting starting points for today's science and health care.
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Touchy subject: 3D printed fingertip 'feels' like human skin
A highly sensitive, 3D-printed fingertip could help robots become more dexterous and improve the performance of prosthetic hands by giving them an in-built sense of touch.
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Tuesday, April 5, 2022
Engineers point the way to more affordable, sustainable urban neighborhoods
Analysis presents a first-of-its-kind framework to design the most efficient mix of urban buildings along with integrated systems to supply power and water services. The approach could significantly reduce costs and pollution compared to traditional systems.
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Sugar-coated nanoparticles target macrophages, reverse pulmonary fibrosis
Scientists have developed a treatment for pulmonary fibrosis by using nanoparticles coated in mannose -- a type of sugar -- to stop a population of lung cells called macrophages that contribute to lung tissue scarring. The cell-targeting method holds promise for preventing this severe lung scarring disease, which can result in life-threatening complications like shortness of breath.
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Treated plastic waste good at grabbing carbon dioxide
Rice University chemists treat waste plastic to absorb carbon dioxide from flue gas streams more efficiently than current processes.
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Women seen as happy and men as angry despite real emotions
Faces and voices are more likely to be judged as male when they are angry, and as female when they are happy, new research has revealed. The study found that how we understand the emotional expression of a face or voice is heavily influenced by perceived sex, and vice versa. He said: "This study shows how important it is not to rely too much on your first impressions, as they can easily be wrong. "Next time you find yourself attributing happiness or sadness to a woman be aware of your bias and possible misinterpretation."
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The pleasant smell of wet soil indicates danger to bacteria-eating worms, researchers find
Researchers have found that geosmin is made by certain kinds of bacteria that are known toxin producers. This acts as a warning to C. elegans, a common type of worm, that the bacteria they are about to graze on is poisonous. The chemical is an aposematic signal that triggers the blind worm's sense of taste just like a caterpillar's bright colors or a pufferfish's spines tell a sighted predator to stay away.
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Sport improves concentration and quality of life
Physically fit primary school pupils feel better and can concentrate better. They are more likely to make it to higher-level secondary grammar schools than children with less sporting ability.
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Monday, April 4, 2022
Sunday, April 3, 2022
Saturday, April 2, 2022
CRISPR and HIV: New technique in human blood unveils potential paths toward cure
Gene editing used to discover human proteins hijacked by HIV to replicate in blood • By better understanding how the virus replicates, treatments could one day become cures • 'This new assay is the most faithful representation of what's happening in the body during HIV infection that we could easily study in the lab,' researcher says • Over half the genes identified in the study had never been looked at in the context of HIV infection
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New research shows survival rate improvement for extremely pre-term infants
A study conducted at 19 medical centers from 2013-2018 found that the survival rate of babies born at 22 weeks (30%) and 23 weeks (55.8%) had increased significantly compared to the same study conducted from 2008-2013, in which only 7% of babies born at 22 weeks and 32% born at 23 weeks survived.
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CRISPR and HIV: New technique in human blood unveils potential paths toward cure
Gene editing used to discover human proteins hijacked by HIV to replicate in blood • By better understanding how the virus replicates, treatments could one day become cures • 'This new assay is the most faithful representation of what's happening in the body during HIV infection that we could easily study in the lab,' researcher says • Over half the genes identified in the study had never been looked at in the context of HIV infection
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Friday, April 1, 2022
Volcano monitoring at Mount Etna using fiber optic cables
In order to understand and predict volcanic events even better, a better understanding of the diverse underground processes involved is required. A new way to detect such processes, even if they are very subtle, is to use fiber optic cables as sensors. The analysis of light that is backscattered in them when the cables are deformed by vibrations, for example, has now made it possible for the first time to determine the volcanic signature of the Sicilian volcano Etna very precisely.
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Study sheds light on why immunodeficiency affects only one identical twin
Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.
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Ozone may be heating the planet more than we realize
New research reveals ozone in the lower atmosphere in particular contributed to warming in the Southern Ocean - which absorbs much of the planet's excess heat - more than previously realized. The study shows that ozone is more than just a pollutant, but also may be playing a significant role in climate change.
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Million-year-old Arctic sedimentary record sheds light on climate mystery
New research provides a continuous look at a shift in climate, called the Mid-Pleistocene Transition, that has puzzled scientists.
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Wildfire smoke exposure in early pregnancy affects infant monkey behavior
Infant monkeys conceived while their mothers were naturally exposed to wildfire smoke show behavioral changes compared to animals conceived days later, according to a new study.
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Higher blood fats more harmful than first thought
The increased levels of blood fats in people with type 2 diabetes and obesity are more harmful than previously thought, a new study has found. The research shows they can kill cells, make symptoms more severe, and worsen the illness. Increased fat in the blood has long been known to damage tissues and organs, contributing to the development of cardiovascular and metabolic diseases including type 2 diabetes.
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Origins of the Avars elucidated with ancient DNA
Less known than Attila's Huns, the Avars were their more successful successors. They ruled much of Central and Eastern Europe for almost 250 years. We know that they came from Central Asia in the sixth century CE, but ancient authors and modern historians debated their provenance. Now, a multidisciplinary research team of geneticists, archaeologists and historians has obtained and studied the first ancient genomes from the most important Avar elite sites discovered in contemporary Hungary. This study traces the genetic origin of the Avar elite to a faraway region of East Central Asia. It provides direct genetic evidence for one of the largest and most rapid long-distance migrations in ancient human history.
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